Study of methylation status in APC gene in Colorectal cancer patient

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 375

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شناسه ملی سند علمی:

CANCERMED04_026

تاریخ نمایه سازی: 17 مرداد 1398

چکیده مقاله:

epigenetic mechanisms such as hypermethylation Materials and Methods: To evaluate the frequency of methylation of APC gene in patients with Colorectal cancer, the methylation specific PCR using exon 18 (MS-PCR) PCR and restriction enzyme (PER) was dependent. Results: After examining 40 patients with Colorectal cancer by MS-PCR and PER hypermethylation in 70 % and %55 , respectively, were found. Discussion : Background check pathologic tissue samples of cancer patients showed that the APC gene inactivation may be performed in the early stages of cancer and epigenetic factors influencing the progression of cancer.

کلیدواژه ها:

Colorectal cancer ، methylation ، tumor suppressor gene APC ، MS-PCR ، PER

نویسندگان

Soheile Asoudeh

Ph.D candidate of Molecular Genetics. Young Researchers and Elite Club, Marvdasht Branch, Islamic Azad University Marvdasht, Iran.