The effects of microgravity on silver nanoparticles and DNA binding

Microgravity is the condition in which objectsorpeople appear to be weightless. The effects ofmicrogravity can be seen when astronauts and objects float in space. Microgravity can be experienced inother ways, as well. Micro- means very small, thus microgravity refers to the condition where gravityseems to be very small. Cancer harms the body when altered cells divide uncontrollably to form lumps ormasses of tissue called tumors (except in the case of leukemia where cancer prohibits normal bloodfunction by abnormal cell division in the blood stream).Chemotherapy is the treatment of cancer with oneor more cytotoxic chemotherapeutic agents as part of a standardized regimen. The term encompasses adiversity of drugs, which are divided into broad categories.In this research, we have studied the effects ofmicrogravity in the interaction between silver nanoparticles and DNA using UV-visible spectroscopy andFT-IR spectroscopyat 37 ˚C for a period of time. Our results display that silver nanoparticles havedifferent effects on DNA structure and DNA binding in gravity and microgravity conditions. The resultobtaining from this present study probably provide useful information to design better drug for cancertherapy and therefore developing more efficiency anti cancer drug in the future.

کلیدواژه ها:

Cancer ، DNA ، Silver nanoparticles ، Thermodynamic parameters