Cytotoxic Activities of Salvia Sahendica Extract on HeLa Cells

The study was aimed to evaluation of the anticancer activity of the Salvia sahendica on the HeLacell line. The cytotoxicity of S. sahendicaon HeLacell was evaluated by the MTT assay.Results showed thatS. sahendicaethanolic extract has significant cytotoxiceffect on HeLacell line in concentration range between 0.156 mg/ml to 1.25 mg/ml. Maximum cytotoxiceffects were found in HeLa cells after incubation with the S. sahendica extract at 0.625 mg/ml (68.02%). Also results showed the concentrations producing 50% growth inhibition (IC50) of the S. sahendica extracts was 3.45 mg/ml. The S. sahendica extract was found dose inhibits the proliferation of cancerous HeLa cells possibly couses through rich secondary methabolits. Based on the results of this experiment extract of S. sahendica has cytotoxiceffect on HeLa cell line, and could be usefull in variety fields as the anticancer complex.

کلیدواژه ها:

Salvia sahendica ، ethanolic extract ، cytotoxic ، MTT assay