Doxorubicin-loaded Perfluorocarbon Nanodroplets for Ultrasound –Mediated Chemotherapy

Two important parameters that should be considered for preparing drug carries are the size of particles and drug entrapment efficiency. The aim of the present study was to formulate doxorubicin-loaded alginate stabilized perfluorohexane (PFH) nanodroplets and evaluate the effects of formulation variables (polymer concentration, surfactant concentration and PFH volume fraction) on particle size and entrapment efficiency of nanodroplets.Particle size (ranged from 40 to 150 nm) and doxorubicin entrapment efficiency (ranged from 85% to 98%) were highly affected by formulation variables. Thus, it was concluded that particle size, entrapment efficiency could easily be adjusted by taking advantage of formulation variables

کلیدواژه ها:

Nanodroplets ، Formulation Variables ، Drug Delivery ، Ultrasound