Synthesis and structural determination of new derivative of Calix-N-Aryle-sulfonamide

A calixarene is a macrocycle or cyclic oligomer based on a hydroxy alkylation product of a phenol and an aldehyde [1]. Calixarenes have hydrophobic cavities that can hold smaller molecules or ions and Calixarenes in general, and more specifically calix[4]arenes have been extensively used as host-guest chemistry [2]. In this project, the aim is synthesis of 5,11,17,23-tetra phenyl sulfamoyl Calix[4]arene (3) and anti bacterial study. For this mean, the effect of sulfonamide unit will be examined on anti-bacterial behavior.5,11,17,23-tetra phenyl sulfamoyl Calix[4]arene (3) were synthesized from 5,11,17,23-tetra chlorosulfonyl calix[4]arene (2). For synthesis of 2, 5,11,17, 23-tetra tert-butyl-calix[4]arene via direct chlorosulfonation by chlorosulfonic acid at the upper rim functionalized (Scheme) [3].