Design, synthesis and biological evaluation of chromon derivatives as a new class of Hsp70 inhibitors

Chromones represent the most common heterocyclic system in natural compounds and serve as the basis of flavonoid structures[1]. In the present study, five bioactive chromone-based compounds were synthesized using 3-formyl-6-methylchromone and some arylamine such as 2-aminobenzamide, 4-aminophenole, glycine 4- aminoacetanilide by the condensation reaction under reflux conditions. The structure of synthesized compounds was characterized and confirmed by the FT-IR, 1H NMR and 13C NMR analyzes. The inhibitory effect of the hsp70 protein, synthetic compounds in the in vitro and in vivo environments was studied and significant results were obtained[2]. The control of ATPase activity showed that these compounds effectively inhibit the activity of HSP70 ATPase. The Anti-oxidant and anti-bacterial properties of synthetic compounds was studied[3]. HSP70 inhibitors may be used as synergistic drugs for the treatment of drug resistant cancers[4].

کلیدواژه ها:

Hsp70 ، Chromon ، Apoptosis ، Anti- cancer ، Anti-bacterial ، …