Comprehensive Numerical Simulation of HybridElectrokinetic Separation of Cancer Cells in a HighlyConductive Biological Fluid

In this study, separation of malignant breast cancer cells from white blood cells by means of hybrid AC-electrokinetics in medium of blood plasma (a highly conductive real biological fluid) is numerically investigated. The simultaneous time dependent, three dimensional modelling of electrical,thermal and hydrodynamic phenomena, followed by tracing the particles, is achieved by using the Finite Element method. Simulation of the two-way coupled equations of highly frequent electricity and time dependent heat transfer, is accomplished in this research by using a new computational approach. Moreover, previously deemed inevitable assumptions of diluting the fluid, lowering the electricalconductivity or unwarranted decoupling of equations, are all avoided in this research, while nonzero electrical charge density, thermal gradients of electrical properties and the components of electrothermal force are computed and spatial separation of cells is successfully achieved. The applied numerical approach and results are validated by a previously approved experimental observations

کلیدواژه ها:

Cancer Cell Separation ، Hybrid Electrokinetics ، Dielectrophoresis ، Finite ElementNumerical Simulation ، Highly Conductive Biological Fluid