The Effect of Carboplatin Loaded on the LiposomeNanoparticle on Cancer Malignancies Cell Lines

Carboplatin is chemotherapy drug which is used against some forms of cancer such as ovarian and lung carcinoma. This research was investigated to optimize and assess the Cytotoxicity of carboplatin Nano liposomeson ovarian and lung cancer cell lines.Nanoparticles were prepared using reverse phase evaporation technique and characterized for spectrophotometryanddrug-release properties. In the next step, A2780S and A2780CP (ovarian) and TC1(lung) cell lines were used to determine the rate of nano liposomal carboplatin cytotoxicity. In this research, size and zeta potential are 244.3±16.7nm and -22.9±1.7 mV, respectively. High encapsulation capacity (78.6±3.7%) confirmed the efficiency of reverse phase evaporation technique. The cytotoxic effect of this Nano liposome onall cell lines was significantly increased when compared with free drug (P<0.05).Our findings suggest that carboplatin liposomal Nano carriers could serve as alternative chemotherapy modality for ovarian and lung cancer therapy.

کلیدواژه ها:

Carboplatin ، Liposome nanoparticle ، Nano drug delivery