A common polymorphism in CDKAL1 gene is associated with type 2 diabetes in Tehran lipid and glucose study

Introduction: The major issue to address in diabetes etiology is to identify the genetic changes in the disease and their occurrence in different populations. Uncovering these genetic changes may beimportant in developing potential biomarkers. In recent years, variants of a number of genes have beenassociated to Type 2 Diabetes (T2D); however, the contributions of these genetic variants in different ethnic groups are not similar. Among all T2D susceptibility genes studied before, the strong association has been found with variants in CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1) to thatof T2D implicates wnt-signaling pathway and cell cycle control in the pathogenesis of T2D. Accordingly, this study was carried out to replicate the previous findings in Iranian population using samples from the Tehran lipid and glucose study (TLGS), a large population-based cohort study.Methods: This case–control study consisted of 2173 affected patients and 2400 controls selectingamong TLGS participants. The genetic variants on CDKAL1 namely rs10440833 was genotyped using the Centaurus (Nanogen) platform in DeCODE genetics. Association of risk allele with T2D was examined using plink software after age and sex adjustment. Results: In this study, the minor allele (A) of rs10440833 increased risk of type 2 diabetes 1.14 fold in case group compared to control group (OR:1.14; p= 0.013). Conclusion: The findings revealed the association between the presence of A allele in rs10440833 and T2D among Iranian population which is in agreement with previous results in other ethnicities.

کلیدواژه ها:

Type 2 diabetes ، CDKAL1 ، rs10440833 ، SNP ، TLGS