Satiety Hormones in Pediatric Urinary Tract Infection

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: فارسی
مشاهده: 371

نسخه کامل این مقاله ارائه نشده است و در دسترس نمی باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:

شناسه ملی سند علمی:

CNAMED06_038

تاریخ نمایه سازی: 2 تیر 1397

چکیده مقاله:

Introduction: Urinary tract infections (UTIs) are among common infections in pediatric patients and are associated with anorexia and failure to thrive (FTT) although transient. Appetite regulating hormones may be considered as a causative factor. Leptin is a 16kd protein, secreted by adipocytes, regulates appetite, food intake and body weight via hypothalamic melanocortin-4 receptor (MC-4R). Leptin is also a potential cytokine for inflammation.Ghrelin on the other hand is a regulatory hormone that maintains fat tissues and body composition. Ghrelin is mainly produced in stomach but is also produced in smaller amounts in other organs such as kidneys.Ghrelin stimulates release of growth hormone (GH), increases food intake, and causes weight gain, mainly in fat tissue. Ghrelin increases body fat without extra calorie intake. It is postulated that Ghrelin may make metabolism more efficient.Ghrelin inhibits Leptin receptor, an internal ligand for the growth hormone secretion (GHS-R), so it is likely that there is an association between infection and Ghrelin.The aim of this study was to evaluate serum and urine Leptin and Ghrelin before and after treatment in children with UTI.Material and Methods: A cross-sectional study was performed on 104 children between 2 months to 17 years old who were admitted in nephrology ward of Mofid hospital. They were evaluated by history, physical examination, blood tests and urine analysis, ultrasound, nuclear scan, and in some cases kidney biopsy according to the Glomerular Filtration Rate (GFR) and KDOQI guidelines and instructions. Patients were divided into 5 groups based on CKD stages: results were expressed using descriptive statistics differences considered statistically significant if p<0.05..Results: Of the 104 cases, 56 patients (45%) were male and 48 (46%) were female. The age range was 86.6 ± 9.4 months.High systolic or diastolic blood pressure was present in 37.5% of patients, anemia was seen in 74%, 70% had bone disease and 63% had failure to thrive. The most common etiology of chronic kidney disease was neurogenic bladder and reflux nephropathy in 27.8% and 16.34%, respectively.Twenty percent of patients were in stage 1 CKD, 24% at stage 2, 17% at stage 3, 40% were at stage 4 and 5 and 31.7% of patients had a GFR less than 15 at the time of diagnosis and 11.53% of patients treated with renal replacement therapy (RRT). During the study, 4.8% of patients received a kidney transplant.Conclusion: As renal complications such as hypertension and end stage renal disease are high in neurogenic bladder, this entity should be considered in etiology of CKD in children. Early recognition and management of CKD complications is of utmost importance for improvement of quality of life of these children.

نویسندگان

Mostafa Sharifian

Pediatric Nephrology Research Center (PNRC), Faculty of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Nasrin Esfandiar

Pediatric Nephrology Research Center (PNRC), Faculty of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Azadeh Afshin

Pediatric Nephrology Research Center (PNRC), Faculty of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Shirin Shohadaee

Pediatric Nephrology Research Center (PNRC), Faculty of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran