The Effects of Vitamin E Supplementation on Lipid Profile in Menopausal Women a Randomized Double-Blind Controlled Trial

Backgrounds: Menopause is associated with changes in lipid profile and is known as an oxidative stress risk factor. Different therapeutically strategies have been used in the case of controlling the menopause complications. Vitamin E as a great anti-oxidant possibly can be effective on lipid per-oxidation in menopausal women. We aimed to evaluate the effect of vitamin E supplementation on lipid profile of menopausal women.Material and Method : This double-blind, placebo-controlled, randomized, cross-over, Phase I/II trial study was designed with two 4-week intervention periods and a 8-day washout period between treatments. Eighty-three natural menopause women were participated in the study. The randomized block allocation were used and enrolled women divided in group A (n=41) and group B (n=42). In phase I, one group was given 400 IU/day vitamin E capsule and another group was given placebo capsule for 4 weeks. Then they entered an 8-day wash-out period, subsequently the phase II for a period of 4-week started in which the group that received vitamin E capsule was given placebo (E-P) and the group received placebo was given Vitamin E (P-E). The plasma lipid profile (LDL-C, HDL-C, TC and TG) were assessed before and after of the intervention in each phase and in general by gathering vitamin E and placebo groups in the two phases, separately. The measurement of lipid panel performed by enzymatic colorimetric method. The study results presented as mean ± SD and median (quartile).Result: The levels of LDL-C, HDL-C, TC and TG before the intervention between P-E and E-P groups by Mann-Whitney U tests no remarkable difference were seen (P> 0.05). Also lipid profile measurement before and after intervention in Phase I and II of placebo-vitamin E group did not show significant differences (P> 0.05). However, in Vitamin E-Placebo group it was revealed that the TG factor before (141.74 ± 53.52 mg/dl) and after (167.47 ± 71.32 mg/dl) intervention within phase II had a considerable difference (P=0.010). No significant differences were seen in the lipid profile mean and changes before and after intervention between vitamin E and placebo receivers in both phases (P> 0.05).Conclusion: The study results revealed that vitamin E supplementation had no remarkable effects on lipid profile levels in menopausal women. Widespread use of vitamin E supplementation for protection and control the impact of menopause does not appear warranted. Thus further study with larger sample size, different duration and doses are necessary

کلیدواژه ها:

Antioxidant ، Lipids ، Menopause ، Vitamin E