Importance of Micro RNAs in Polycystic Ovary Syndrome

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 388

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شناسه ملی سند علمی:

COBGY15_127

تاریخ نمایه سازی: 11 آبان 1398

چکیده مقاله:

Backgrounds: Polycystic ovary syndrome (PCOS) is the commonest hormonal disorder affecting 5-10% of female reproductive age in the world, accounting for the majority cases of anovulatory infertility [1, 2] However, PCOS carries the potential to disrupt endometrial intactness and prevent implantation[3].MicroRNAs (miRNAs) are impressive regulators of gene expression that regulate gene expression at the levels of the post translation in some biological processes [4].This molecular RNAs are set up several biological processes [5, 6] and they contribute as biomarker[7].Material and Method: In this study, the related articles for this subject were collected from international databases such as ISI, PubMed and Scopus.Result: Polycystic ovarian syndrome (PCOS) is the most common endocrine pathology in the childbearing age female around the world. Stein and Leventhal described it in 1935[8]MicroRNAs are noncoding RNA fragments that regulate gene expression at the levels of the post translation in aspects of biology[9, 10]and abnormal expression of miRNAs has been associated with various disorders[3].Conclusion: However, expression of microRNAs could be used as biomarkers distinguishing PCOS patients and they could perhaps help to explain the pathogenesis of disease MiRNA might prove promising as biomarker candidates for PCOS patients. Although further research is required in this area.

نویسندگان

Fatemeh Fateh

Master of genetic, Reza Safaralizadeh assistant professor of genetic, Shirin Azarbarzin PHD student Tabriz University Faculty of Natural Sciences