Effects of calcium and vitamin D co-supplementation on markers of inflammation and oxidative stress in overweight and vitamin D-deficient women with polycystic ovary syndrome
سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 504
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شناسه ملی سند علمی:
DTOGIMED03_050
تاریخ نمایه سازی: 26 بهمن 1398
چکیده مقاله:
Background and Aim : This study was conducted to determine the effects of calcium plus vitamin Dsupplementation on inflammatory factors and biomarkers of oxidative stress among overweight vitamin Ddeficientwomen with polycystic ovary syndrome (PCOS).Methods : Methods: This randomized double-blind placebo-controlled clinical trial was performed among104 overweight vitamin D-deficient women diagnosed with PCOS aged 18-40 years old. Participants wererandomly divided into four groups. Group A received 1000 mg calcium daily and vitamin D placebo weekly(n=26), group B 50000 IU vitamin D weekly and calcium placebo daily (n=26), group C 1000 mg calciumdaily plus 50000 IU vitamin D weekly (n=26) and group D calcium placebo daily plus vitamin D placeboweekly (n=26) for 8 weeks. Fasting blood samples were taken at baseline and 8 weeks after intervention tomeasure inflammatory factors and biomarkers of oxidative stress.Results : Results: After 8 weeks, individuals taking calcium plus vitamin D supplements had greaterdecreases in homeostatic model assessment-Beta cell function (HOMA-B) score (-11.1 vs. -8.6, -3.4 and13.7, respectively, P=0.03), serum high sensitivity C-reactive protein (hs-CRP) (-948.3 vs. 802.3, -383.8and 618.2 ng/mL, respectively, P=0.04), plasma malondialdehyde (MDA) concentrations (-0.6 vs. -0.5, -0.1 and 0.6 μmol/L, respectively, P=0.009) and significant increases in plasma total antioxidant capacity(TAC) (35.2 vs. 21.1, 22.5 and -153.8 mmol/L, respectively, P=0.006) and glutathione (GSH) levels (216.0vs. 3.9, -47.5 and -160.8 μmol/L, respectively, P=0.001) compared with calcium alone, vitamin D aloneand placebo groups. Calcium plus vitamin D co-supplementation did not influence plasma NO and catalaselevels. Conclusion : Conclusion: We found that calcium plus vitamin D co-supplementation for 8 weeks amongoverweight and vitamin D-deficient women with PCOS had beneficial effects on inflammatory factor andbiomarkers of oxidative stress.
کلیدواژه ها:
نویسندگان
Zatollah Asemi
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences,Kashan, I.R. Iran
Fatemeh Foroozanfard
Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, I.R.Iran
Fatemeh Naderi
Department of Gynecology and Obstetrics, School of Medicine, Kashan University of Medical Sciences, Kashan, I.R.Iran
Mehri Jamilian
Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences, Arak, Iran