Evaluation of pretreatment with Cetrotide in an antagonist protocol for patients with PCOS undergoing IVF/ICSI cycles: a randomized clinical trial

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 396

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شناسه ملی سند علمی:

DTOGIMED03_053

تاریخ نمایه سازی: 26 بهمن 1398

چکیده مقاله:

Background and Aim : This study aimed to evaluate the effect of three days of GnRH antagonistpretreatment on the preg- nancy outcomes of women with polycystic ovarian syn- drome (PCOS) on GnRHantagonist protocols for IVF/ICSI.Methods : Fifty women with PCOS in the control group received conventional antagonist protocols,starting on day 2 of the cycle. In the pretreatment group (n=38), a GnRH antagonist was administered fromday 2 of the menstrual cycle for three days.Results : Controlled ovarian stimulation (COS) duration and gonadotropin dosages were similar in bothgroups. The number of metaphase II (MII) oocytes, 2PN oocytes, embryos, along with implantation andclinical pregnancy rates, were higher in the pretreatment group when com- pared with controls, althoughthe increment was not sig- nificant (p value ≥0.05). The chemical pregnancy rate was significantly higherin the pretreatment group. The rate of OHSS was significantly lower in the pretreatment than in the controlgroup.Conclusion : Women with PCOS offered early follicular phase GnRH antagonist pretreatment for threeconsecu- tive days had significantly fewer cases of OHSS and higher chemical pregnancy rates. There weretrends toward great- er numbers of MII oocytes, 2PN oocytes, and embryos, and higher clinical pregnancyrates in the pretreatment group.

نویسندگان

Ramesh Baradaran Bagheri

عضو هیات علمی دانشگاه البرز

Maryam Eftekhar

عضو هیات علمی دانشگاه یزد

Robabe Hosseinisadat

عضوهیات علمی دانشگاه کرمان

Nosrat Neghab

فلوشیپ ناباروری اهواز