The effects of zinc supplementation on clinical response and metabolic profiles in pregnant women at risk for intrauterine growth restriction: a randomized, double-blind, placebo-controlled trial

Background and Aim : Background: Data on the effects of zinc supplementation on clinical response andmetabolic profiles in women at risk for intrauterine growth restriction (IUGR) are limited. Thisinvestigation was conducted to assess the effects of zinc supplementation on clinical response and metabolicstatus among pregnant women at risk for IUGR.Methods : Methods: This randomized, double-blind, placebo-controlled, clinical trial was conductedamong 52 women at risk for IUGR according to abnormal uterine artery Doppler waveform. Participantswere randomly assigned to take either 233 mg zinc gluconate (containing 30 mg zinc) supplements (n=26)or placebo (n=26) for 10 weeks from 17-27 weeks of gestation. Fasting blood samples were taken atbaseline and after the 10-week treatment to quantify related variables.Results : Results: After the 10-week intervention, taking zinc led to a significant reduction in serum highsensitivity C-reactive protein (hs-CRP) (β -1.17 mg/L; 95% CI, -1.77, -0.57; P<0.001) and plasmamalondialdehyde (MDA) levels (β -0.23 μmol/L; 95% CI, -0.45, -0.02; P=0.03); also a significant rise intotal antioxidant capacity (TAC) (β 59.22 mmol/L; 95% CI, 25.07, 93.36; P=0.001) was observed incomparison to placebo. In addition, zinc supplementation significantly reduced serum insulin (β -1.33μIU/mL; 95% CI, -2.00, -0.67; P<0.001) and insulin resistance (β -0.30; 95% CI, -0.44, -0.15; P<0.001),and significantly increased insulin sensitivity (β 0.008; 95% CI, 0.003, 0.01; P<0.001) compared with theplacebo.Conclusion : Conclusions: Zinc supplementation did not influence pulsatility index (PI) and othermetabolic parameters. Overall, zinc supplementation in pregnant women at risk for IUGR had beneficialeffects on TAC, MDA, hs-CRP and insulin metabolism, but did not affect PI and other metabolic profiles.

کلیدواژه ها:

Zinc supplementation ، pregnant women ، metabolic profiles ، intrauterine growth restriction