Background and Aim : Breast cancer is the most frequent malignancy in women worldwide. As evidencesuggests that it has invasive biological properties at a young age, chemotherapy is the current standard ofcare for most young patients but is likely to induce ovarian toxicity and infertility after treatment. Infertilityinduced by cancer treatment is a recognized survivor issue and the practice of
fertility preservation isspreading rapidly. Currently established clinical methods of female
fertility preservation include thecryopreservation of embryos and mature oocytes obtained after hormonal stimulation and ovarian tissueretrieval which does not require hormonal stimulation. We wondered whether
fertility preservation with orwithout hormonal stimulation, was associated with an increased risk of
breast cancer recurrence.Methods : A comprehensive search of the literature was undertaken in order to answer the above question.Accessing a range of databases (including library of Cochrane and PubMed), the authors searched for theliterature related to Preservation fertility of
breast cancer women by using this syntax including : 1. Breastcancer (393130) 2. (Breast cancer) AND fertility (1760) 3. (
breast cancer ) AND fertility (1329) 4. (breastcancer recurrence) AND fertility (135) 5. (
breast cancer recurrence ) AND fertility (10) 6. Systematic[sb]AND (
breast cancer recurrence ) AND fertility[tiab](0). After evaluating 10 articles, one article wasselected because of the higher level of evidence (IIB) and answer to the clinical question of the presentstudy. The Quality of journal was Q2. The study was critically evaluated. The methodological quality wasassessed by STROBE checklist.Results : The strongest evidence was in a matched cohort study by Dr Rodriguez-Wallberg and colleagues.This was an analysis of 567 patients women with
breast cancer that 188 women attempting to ensure fertilitypreservation. This study shows that There was no evidence of a statistically significant effect for fertilitypreservation effect with or without hormonal stimulation on the rate of
breast cancer relapse (IRR 0.66,95% CI 0.37–1.17 and IRR 0.83, 95% CI 0.42–1.67).Conclusion : The literature suggests that the importance of fertility issues and addressing fertilitypreservation techniques can be promising in women with cancer and play an important role in improvingtheir relationships and quality of life. The role of health care providers (addressing fertility issues and sexualdesire in women with cancer) is crucial so more research including a longer-term follow-up of a largecohort, is needed to confirm these findings.