Simultaneous measurement of uric acid and dopamine using electrode modified with the carbon Nano tube and copper- Quinizarine nanoparticles

One of the best methods for simultaneous determination of dopamine (DA) and uric acid (UA) in biological samples, without interferences of other species, is electrochemical methods usingmodified electrodes. In this research cupper - Quinizarine nanoparticles (Cu – AQ-NPS) were synthesized via co-precipitation method and then were mixed with Singel wall carbon nano tube(SWCNT). This mixture was utilized for the modification of the surface of a glassy carbonelectrode. The modified electrode was used for simultaneous determination of DA and UA Study the electrochemical behavior of the modified electrode in acetate buffer solution with pH=5 using cyclic voltammetry technique revealed that this electrode could exhibit an oxidationpeak for DA and also an good oxidation peak for UA (Fig. 2, 3). Under optimized conditions the detection limit were obtained as 0.88 μM and 1.42 μM for DA and UA, respectively. Precision and accuracy of the proposed method for simultaneous analysis of DA and UA are in acceptable range and eventually the modified electrode was successfully used for determination of DA and UA in human blood serum samples

کلیدواژه ها:

Dopamine ، Uric acid ، Cupper - Quinizarine Nanoparticles ، Modified Electrode