Modified carbon paste electrode by multi-walled carbon nanotubes for Potentiometric determination of alprazolam in pharmaceutical formulations, human plasma and urine

For the first time a novel derivatized multi-walled carbon nano tubes-based on alprazolam carbon paste electrodes is reported. At optimum values of variable conditions, the proposedelectrodes responded toward alprazolam linearly in the range of 5.0×10-10-5.0×10-4 mol L−1 with slope of 19.71±0.2 mVdecade−1 of alprazolam concentration and detection limit of 1.3×10-9 mol L−1 for ALP/MWCNTs-CPE (electrode (VIII)). The electrode response is independent of pH inthe range of 2–8, with a fast response time (8 s) at 25 oC for electrode (VIII). Moreover, the electrodes also showed high selectivity and long life time (more than 10 weeks) for electrode (VIII). The electrodes showed good selectivity for alprazolam toward wide variety of species.The proposed sensors were successfully applied for the determination of alprazolam in pharmaceutical formulations, human plasma and urine as indicator electrodes.

کلیدواژه ها:

Potentiometry ، Alprazolam determination ، multi-walled Carbon nanotube ، carbon paste electrode ، Pharmaceutical formulations