Preparation and characterization of a novel nanosensor based on iron oxide nanoparticles for electrochemical studies of epinephrine

سال انتشار: 1394
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 301

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شناسه ملی سند علمی:

ELECTROCHEMISTRY011_287

تاریخ نمایه سازی: 5 بهمن 1395

چکیده مقاله:

Epinephrine or 4-(1-hydroxy-2-[methylamino]ethyl)-1,2-benzenediol hydrochloride (Epi),belongs to the family of catecholamine neurotransmitters, which is widely distributed in themammalian central nervous system for message transfer process. It is as an important chemical mediator for conveying nerve impulse in the mammalian central nervous systems. Furthermore, Epi can be used to treat cardiac arrest and bronchodilator for asthma patients [1]. Therefore, aquantitative determination of Epi is quite helpful for developing research in disease diagnosis, pharmacological research and life science. Epi shows an electroactive nature [2], so electrochemical methods along with modified electrodes can be useful for its sensitive detection.In the present study, a simple strategy for determination of Epi based on iron oxide nanoparticles modified carbon paste electrode is reported. The iron oxide nanoparticles displayed higheffective surface area, high porosity, more reactive sites and excellent electrochemical catalytic activity toward the oxidation of Epi. The characterization of the modified nanosensor was carried out by different techniques such as X-ray diffraction (XRD), scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). Theelectrochemical oxidation of Epi has been studied using CV and differential pulse voltammetry (DPV) techniques at the surface of the modified electrode. After optimizing the experimentalconditions, the anodic peak current of Epi showed a linear correlation to its concentration in abroad linear dynamic range (0.4-270μM) with low limit of detection (19 nM). Also the modified nanosensor presented a good stability and repeatability toward the determination of Epi. Finally, the proposed method was successfully applied for the determination of Epi in real samples.

نویسندگان

Sayed Mehdi Ghoreishi

Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, IR Iran

Asma Khoobi

Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, IR Iran

Nasrin Heydarzade Arani

Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, IR Iran