Electrochemical sensor based on surface modification of graphene nanosheetswith gold nanoparticles for determination of 5-fluorouracile anticancer drug

سال انتشار: 1395
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 291

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شناسه ملی سند علمی:

ELECTROCHEMISTRY012_135

تاریخ نمایه سازی: 5 آذر 1397

چکیده مقاله:

In this paper, we selected electrochemical strategy to determination of 5-fluorouracile bygraphene-Au NPs nanocomposites-modified glassy carbon electrode (GN/Au NPs/GCE). 5-Fluorouracil (5-FU) is an anti-neoplastic agent, it has been used for the treatment of solid tumorsof the breast and rectum [1]. It is also used in treatment of colorectal cancer, and pancreaticcancer. High over voltage of drugs, especially cancer drugs, at a bare electrode suggestednecessary modification of electrodes with conductive materials such as polymers, electroactivemediator and nanocomposites [2, 3]. Graphene together with its, various derivatives, such asgraphene oxide, graphene nanoribbon, chemically reduced graphene oxide [4, 5] has shownfascinating advantages in electrochemistry such as electrochemical devices and capacitors due toits remarkable electrochemical properties. Especially, a chemically reduced graphene nanosheet(cr-Gs) is popular and robust in bioelectrochemistry communities because of its easyfunctionalization, rich surface chemistry, and biocompatibility [6-8]. Many efforts have beendevoted to improve the capability of cr-Gs through association of cr-Gs with metallicnanoparticles. Gold nanoparticles are always considered as an advanced candidate due to theiramazing surface properties and quantum-mechanical rules with diameters less than 10 nm [9, 10].For example, graphene-Au NPs (GN/Au NPs) nanocomposites have been used as substrates ofsurface enhanced Raman scattering (SERS), hydrogen peroxide sensor and monolayer graphenefabrication [11-13]. On the basis of the outstanding properties of GN/Au NPs nanocomposites inelectronics and chemistry, it is highly desired to be used as the sensing platform inelectrochemical biosensors for sensitive detections. Herein, the electrochemical behavior of 5-FUwas investigated employing cyclic voltammetry (CV), chronoamperometry (CA) and electrochemical impedance spectroscopy (EIS). After optimization of experimental conditions,the electro-oxidation peak currents for 5-FU at pH 9.0 phosphate buffer solution was found tovary linearly with its concentrations in the range of 0.1–50.0 μM using differential pulsevoltammetry (DPV) method. The detection limit is 0.04 μM. Furthermore, GN/Au NPs/GCE wassuccessfully applied for the analysis of 5-FU in blood serum samples with recovery 100.5% and99.23% respectively. The modified electrode showed good stability and repeatability.

نویسندگان

M Mazloum‐Ardakani

Department of Chemistry, Faculty of Science, Yazd University, Yazd, Iran

H Mohammadian-Sarcheshmeh

Department of Chemistry, Faculty of Science, Yazd University, Iran

A Khoshroo

Department of Chemistry, Faculty of Science, Yazd University, Yazd, Iran