Glioblastomas and Genetic Counseling

Background and Aim : Persons carrying mutations for hereditary cancer syndromes are at high risk for the development of tumors at an early age. The genetic causes of many hereditary cancer syndromes have already been identified. Hereditary cancer syndrome leads to 5% of all cancers. About 1% of gliomas is derived from these hereditary tumor syndromes. The majority of gliomas are non-syndromic glioma. There is little data on glioblastomas and their relationship with this disease. Some of the familial syndrome such as tuberous sclerosis, Turcot s syndrome, Li-Fraumeni s syndrome, and neurofibromatosis type 1, can predispose an individual to glioblastoma. This study aims to discuss molecular, clinical, and statistical data of glioblastomas that related to inherited syndromes. Methods : We investigated published glioblastoma case series studies, from 2015 to 2018. Results : This paper summarizes knowledge about rare familial cancer syndromes that include adult glioma and reviews the available literature on the more recently discovered common inherited glioblastoma.Conclusion : Understanding of molecular abnormalities in the syndromic and non-syndromic glioblastoma should help understand the mechanisms of gliomagenesis. A patient with high-grade glioma requires the physician to actively search the possible inherited factors and eventually suggest genetic counseling.

کلیدواژه ها:

Glioblastoma ، Genetic Counseling