Effect of phototherapy on serum zinc level in term neonate with Hyperbilirubinemia

Background Several effects and complications have been reported for phototherapy including dehydration, diarrhea, and THE effect on platelet counts, calcium and magnesium level, but less has been done for the effect of phototherapy on serum zinc level. This study was carried out to determine the effect of phototherapy on a serum zinc level in full term neonates with hyperbilirubinemia (HB). Material and MethodsIn a cohort study, the serum zinc level of neonates with hyperbilirubinemia with an age more than 72 hours was measured using flame atomic absorption method (PG 990 AAS England) before and after phototherapy and compared with the neonates with physiologic jaundice in which phototherapy was not indicated. P-values less than 0.05 were considered significant.Results: A total of 120 neonates (60 without phototherapy and 60 with phototherapy) were enrolled in this study. The mean serum zinc level in those without phototherapy increased from 77.14±43.91 to 101.59±40.63 µg/dl (P=0. 004) in the first days of life and 72 hours later, respectively, but in those neonates with phototherapy decreased from 110.21±43.66 to 101.60±34.68 µg/dl (P=0. 238) before and after phototherapy. Comparison of changes in serum zinc level between two groups suggest that serum zinc level decreases after phototherapy (P= 0.003). Conclusion: Phototherapy in term neonates with hyperbilirubinemia could inhibit the physiologic increase of serum zinc level after birth.

کلیدواژه ها:

Hyperbilirubinemia ، Phototherapy ، Zinc ، Infant ، Newborn