The role of angiogenesis in acute and chronic lymphoblastic leukemia

Angiogenesis is typically a physiological process of formation of de nove blood vessels from pre-existing vasculature. This process is result of a balance between proand anti-angiogenic factors. Disruption of this balance lead to pathological angiogenesis. Angiogenesis have been demonstrated as an important feature in growth and viability of solid tumors. Several data bring up the suggestion that angiogenesis plays an important role in pathogenesis of leukemia, especially in AML and CML. Butangiogenesis in acute and chronic lymphoblastic leukemia and the change in serum levels of pro-angiogenic (VEGF, PIGF and so on) and anti-angiogenic factors (sFLT1 and sEng) is less have been studied. Aim: the aim of this review is to study the relevant literature about angiogenesis and the change in pro and anti-angiogenic factors in ALL and CLL patients compare to normal stat and report a conclusion. Method: relevant database including Pubmed, Google scholar and medline were searched from 2000 to 2019 and irrelevant studies were excluded and the rest of them were checked. Conclusion: patient with ALL and CLL have increased microvessel density (MVD) and pro and anti-angiogenic cytokines compared to normal controls. The combination of chemotherapy and antiangiogenic agents can be a promising successful therapeutic approach in treatment of ALL and CLL patients, which are performing in experimental trials.

کلیدواژه ها:

Angiogenesis ، lymphoblastic leukemia ، pro and anti-angiogenic factors