The synthesis of novel isatin based furan derivatives using multi–component reactions

A simple synthesis of highly functionalized 2,5-diaminofurans based derivatives from 1-(carboxymethyl) isatin via a multi-component reaction is described. The reactive 1:1 intermedi -ate produced from the reaction of isocyanides and dialkyl acetylene – dicarboxylates was trapped at room temperature by 1-(carboxymethyl)isatin derivatives to yield polyfunctionalized furan rings in fairly good yields.

کلیدواژه ها:

isatin ، one-pot ، multi-component reaction ، isocyanides ، furan ، dialkyl acetylene- dicarboxylates