Atomistic insights into the Protein-functionalized nanoparticles
محل انتشار: هفتمین همایش بیوانفورماتیک ایران
سال انتشار: 1396
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 497
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شناسه ملی سند علمی:
IBIS07_092
تاریخ نمایه سازی: 29 فروردین 1397
چکیده مقاله:
Protein-functionalized nanoparticles can be used in various pharmaceutical approaches but the choice of nanoparticle size, shape, charge, linking chemistry, protein-labeling site, etc. remains challenging due to their effect on protein structure and function. Here molecular dynamics simulation was used as a functional way to predict atomistic insights into the charge of polystyrene nanoparticle and epidermal growth factor stability as a model of the nanoparticle-protein complex. Our result showed that the epidermal growth factor orientation regarding the conjugation is suitable and the RMSD analysis represents the complex stability during MD simulation
کلیدواژه ها:
نویسندگان
S Yasami Khiabani
Department of Biomedical Engineering, AmirKabir University of Technology, Tehran, Iran
H Rahimi
Molecular Medicine Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran
M Golkar
Molecular Parasitology Laboratory, Department of Parasitology, Pasteur Institute of Iran, Tehran, Iran
A Karkhaneh
Department of Biomedical Engineering, AmirKabir University of Technology, Tehran, Iran