The Experience of Use Triple Antithrombotic Therapy in Patients With Acute Coronary Syndrome and Atrial Fibrillation
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 297
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شناسه ملی سند علمی:
ICACSMED02_060
تاریخ نمایه سازی: 30 دی 1397
چکیده مقاله:
BACKGROUND: In real life to evaluate the effectiveness and safety of apixaban with double antiplatelet therapy for prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation and the recent episode of acute coronary syndrome without ST segment elevation.METHODS: 12 patients in hospitals of Isfahan with atrial fibrillation and the recent (8-14 days after the onset of symptoms of ACS) episode of acute coronary syndrome without ST segment elevation were involved into the research. The effectiveness (deaths, stroke and systemic embolism) and the safety (major clinically significant and not significant bleeding) were investigated within 3 months.RESULTS: There were no any strokes, systemic embolism, deaths during observational period. Nasal and mild gingival hemorrhages (not requiring medical intervention) were noted in 3 patients during the first month of treatment and one patients experienced non-permanent petechiae. Major and clinically significant bleeding was not registered.CONCLUSIONS: The use of oral anticoagulant apixaban 5 mg BID or 2.5 mg BID with double antiplatelet therapy in patients with non-valvular atrial fibrillation and the recent episode of acute coronary syndrome without ST segment elevation is effective and safe for the prevention of stroke and systemic embolism during 3 months of treatment. Future researches are required.
کلیدواژه ها:
acute coronary syndrome without ST segment elevation ، apixaban ، atrial fibrillation ، systemic embolis
نویسندگان
Seyed Ehsan Asadi
Anesthetist and Critical Care Student of Isfahan University ,Isfahan .Iran
Farhad Salabat
Anesthesiologist .Isfahan .Iran
Ahmad Rahimi
Medical Student of Isfahan University ,Isfahan .Iran