Coronopilin-loaded PLGA-PEG nanoparticles as breast cancer drug-delivery system

Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females. Medicinal plants are significant in drug discovery for treatmentof human diseases, and their secondary metabolites have proven to be a trustworthy source of new and effective anticancer agents. Sesquiterpene lactones compose alarge group of natural products, and often are the active components of great numbers of traditional medicinal plants. Coronopilin is a sesquiterpene lactone with many anticancer activities. On the other hand, there is potential for use of nanoparticles for biomedical application. Poly (lactic-co-glycolic acid) (PLGA) is one of the most efficiently developed biodegradable polymeric nanoparticles. PLGA-PEG has been the center of attention for developing drug-loaded nanoparticles for cancer therapy. Therefore, the aim of this study was to investigate inhibitory effect of Coronopilinloaded PLGA-PEG nanoparticle on T47D breast cancer cell line as in vitro model of breast cancer.Materials and methods: The study was conducted on T47D, breast-derived cell lines. Cytotoxic effect of Coronopilin-loaded PLGA-PEG nanoparticles on T47D breast cancer cell line wasevaluated by 24h MTT assays. Results: Coronopilin-loaded PLGA-PEG nanoparticles inhibited breast cancer cell population growth. Data analysis showed that Coronopilin has dose-dependent cytotoxic effect on T47D breast cancer cell line with IC50 = 34 μg/ml. Conclusions:This study demonstrated that Coronopilin-loaded PLGA-PEG nanoparticlesefficiently inhibited cancer cell population growth. Moreover, Coronopilin-loaded PLGA-PEG nanoparticle has cytotoxic effect on T47D breast cancer cell line. Thus,drug-loaded PLGA-PEG nanoparticle may represent an interesting new chemical scaffold upon which to develop new anti-breast cancer agents

کلیدواژه ها:

Breast cancer ، Coronopilin ، PLGA-PEG nanoparticles ، Sesquiterpene lactones