Combination Therapy of siRNA and Chemotherapy in Breast Cancer
محل انتشار: دهمین کنگره بین المللی سرطان پستان
سال انتشار: 1393
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 453
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شناسه ملی سند علمی:
ICBCMED10_050
تاریخ نمایه سازی: 21 اردیبهشت 1397
چکیده مقاله:
Breast cancer is a worldwide leading cause of death. The treatment modalities for breast cancer are surgery, hormone therapy, radiotherapy, chemotherapy and antisense therapy (include siRNA).The poor results obtained with single siRNA delivery have encouraged the development of concomitant strategies by use single siRNA with other therapeutic agents like Doxorubicin. Association and synergy between siRNA and doxorubicin also reduce toxicity of doxorubicin because of use in combination with siRNA, that allowing the use a lower dose of doxorubicin, cause improve their therapeutic effect on breast cancer. This method could overcome potential drug resistance by combining agents with different mechanism of action. Combination therapy successfully applied in the treatment of many types of cancer specially breast cancer. In addition, it will also assess these synergistic effects on other types of cancer and in combination with other drugs.
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نویسندگان
Ghasem Khazaei
Msc student of Human Genetics, Golestan University of Medical Sciences
Parham Nejati
Msc student of Human Genetics, Golestan University of Medical Sciences
Shayesteh Rezayani
Msc student of Molecular Genetics, Azad University of Damghan