Dose history of induced abortion increases the risk of breast cancer

Introduction Breast cancer is the leading cause of cancer death among women but the potential causes remain unclear. Most of the studies have shown the association of reproductive factors with breast cancer risk. So the present study was conducted to determine whether induced abortion, as a reproductive factor, is risk factor of breast cancer. Result In the studies reviewed, induced abortion was known as a protective factor and also as a risk factor for breast cancer. As risk factor, breasts of women who undergo abortion are exposed to high hormone levels typical of early normal pregnancy, but then do not experience the terminal cell differentiation that occurs late in a normal pregnancy, so leaving breast tissue immature with more sites for cancer initiation and more vulnerable to carcinogens. As protective factor, it shows when the times of inducedabortion increasing, the non-differentiated cells would be decreasing, and the susceptibility of epithelial cells to future carcinogenic stimuli would be decreasing too. It has been found even among BRCA2 mutation carriers.Conclusion Due to the presence of conflicted findings and unknown etiology in this domain, further studies are required.

کلیدواژه ها:

Breast cancer ، abortion ، risk fact