Downregulation of Differentiation Antagonizing long None Coding RNA (DANCR) and its ceRNA network target gene, CTNNB1, in breast cancer tissues and adjacent non-neoplastic tissues of Iranian Turkish breast cancer patients

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 445

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شناسه ملی سند علمی:

ICBCMED14_126

تاریخ نمایه سازی: 21 مرداد 1398

چکیده مقاله:

Introduction & Aim: Breast cancer (BC) is the second most common cause of cancer-related death amongst females which requires an exploration for markers to propose a more specific categorization of this cancer. Long noncoding RNAs (lncRNAs) as the main subset of noncoding transcripts have been shown to be involved in tumorigenic processes. In this study, we investigated expression of differentiation antagonizing non-protein coding RNA (DANCR) and its ceRNA network target gene, catenin beta 1(CTNNB1), in 61 breast cancer tissues and their adjacent noncancerous tissues (ANCTs). Furthermore, the relationship of lncRNA DANCR and CTNNB1 gene with various clinical features of patients were analyzed. Methods: The expression of mentioned genes was assessed by quantitative real time-PCR in 61 samples of invasive ductal carcinoma of breast in comparison with their ANCTs in a cohort of Iranian Turkish breast cancer patients. Results: DANCR and CTNNB1 genes have been shown to be down-regulated in breast tumor samples compared with their paired ANCTs (P=0.008). In addition, the results showed that the expression of lncRNA DANCR and CTNNB1gene was significantly associated with histological grade, TNM stages, lymph node involvement and also metastasis (P<0.05). Conclusion: DANCR and CTNNB1 genes usually are up-regulated in various cancers including hepatocellular carcinoma, colorectal and breast cancers. In contrast to the previous studies about breast cancer, in our cohort a down-regulation of DANCR lncRNA in BC was found which supports recent investigation of Foroughi.et al on gastric cancer tissues.

نویسندگان

Zeynab Shaghaghi Torkdari

Associate Professor, Department of Genetics, Animal biology Group, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran

Mohammad Khalaj Kondori

PHD student, Department of Genetics, Animal biology Group, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran

Mohammad Ali Hosseinpour Feizi

Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran

Vahid Montazeri

Department of Thorax Surgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran