Mechanically strong dual responsive double network hydrogel for controlled drug release of Doxorubicin

Mechanically strong dual/multi-stimuli-responsive smart hydrogels have attracted extensive attention in recent years. A novel tough, mechanical strong and biocompatible dual pH- and temperature - responsive poly(acrylamide) (PAAm) / ion cross-linked calcium-alginate double network hydrogelswas synthesized through a facile, one-pot free radical polymerization initiated by the ultraviolet light, for synthesizing the mechanical strong hydrogels were investigated. In comparison to the sodium alginate/PAAm hybrid gel, the as-fabricated calcium- alginate/PAAm gel demonstrated superior mechanical properties. After soaking in calcium chloride (Cacl2 ) solution, the size of the as-synthesized hybrid gel can be well controlled without observable volumetric swelling through manipulating the equilibrium between shrinkable elastic energy from ionic (ca2+ ) bonds and swelling osmotic energy. This material design and processing technology are promising to fabricate complicatedshaped cartilage with high geometric fidelity. After soaking in 8 wt% Cacl2 solution for 2 h, compressive strength of calcium-alginate/PAAm gel was significantly improved by 92 % compared to PAAm single network hydrogel, meanwhile the size and shape of calcium-alginate/PAAm gel were nearly changed and deformed, respectively. Furthermore, the relationship between swelling and deswelling rate of the synthesized hydrogels and the above crucial factors were also studied. Besides, the synthesized hydrogels displayed a considerable controlled release property of Doxorubicin by tuning their inner crosslink density. Owing to this property, they may have great potential in the drug delivery systems

کلیدواژه ها:

Dual-responsive ، biocompatible ، mechanically strong ، double network ، drug delivery systems