CoFe2O4-nanoclinoptilolite as a nanocatalyst for the synthesis of pyrazole derivatives under aqueous media

CoFe2O4-nanoclinoptilolite has been synthesized as a nanocatalyst, according to a simple method by using CoCl2 and FeCl3 and clinoptilolite powder in distilled water. Then a simple and efficient procedure for the synthesis of pyrazole derivatives via the reaction 1,3-diketone/ketoester with phenyl hydrazines in the presence of CoFe2O4-nanoclinoptilolite has been developed. Pyrazole derivatives have been widely applicated in the clinically useful drugs. This nanocatalyst has significant advantages such as: excellent product yields, solvent free conditions and very short reaction times. The nanocatalyst was easily separated with the filtration and reused for several times without any loss of its catalytic activity

کلیدواژه ها:

nanocatalyst ، CoFe2O4- nanoclinoptilolite ، pyrazole