The Role of Obesity Collaborated with Inflammation Phenotypes in the Prediction of Type 2 Diabetes

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 512

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شناسه ملی سند علمی:

ICEMU05_039

تاریخ نمایه سازی: 9 آذر 1398

چکیده مقاله:

Introduction: The aim of the present study was to investigate the relationship between obesity collaborated with WBC count and the incidence of T2D in first degree relatives of patients with type 2 diabetes.Materials & Methods: In a prospective population based cohort study, a total of 2839 participants were followed up from 2003 to 2018.Results: At the end of the 15-year follow-up period (median duration of follow-up, 9 years; interquartile range, 5-12 years), 15.1% of participants developed T2D. The incidence of T2D was 23.8 per 1000 person-years (18040 person-years). The multivariate Cox proportional-hazards regression models revealed that development of T2D is significantly associated with Joint obesity and WBC count. The hazard ratios (95% CI) of T2DM are shown in the table 1.The Kaplan-Meier Product-Limit estimates show that the mean time for development of T2D for non-obese participants with low WBC count, non-obese participants with high WBC count, obese participants with low WBC count and obese participants with high WBC count were; 14.1 (13.4–14.9), 12.9 (11.9-13.9), 12.9 (12.5-13.4) and 12.1 (11.7-12.6), respectively; (Gehan-Breslow-Wilcoxon Test p<0.0001).Conclusion: The results of present study demonstrated that WBC count along with obesity as a predictor is associated with increased risk of type 2 diabetes mellitus.

نویسندگان

Mojtaba Akbari

Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Masoud Amini

Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Ashraf Aminoroaya

Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Awat Feizi

Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Biostatistics and Epidemiology, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

Mahboobeh Shakeri

Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Ali Ebrahimkhani

Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran