Functionalized Mesoporous Silica Nanoparticles as a Novel AntioxidantDelivery System

Antioxidants have an important role in control and prevent from dangerous diseases like cancers who knows as a main reason of death, but the antioxidants' stability and high solubility are major challenges of pharmaceutical researchers. Then using carrier for antioxidant can enhance antioxidant stability and protect it from reaction with the other existing molecules in the blood circulation. Mesoporous silica nanoparticles (MSNs) have been widely used as carriers for therapeutic applications because of their good biological properties. This study attempts to improve surface properties and increase antioxidant loading by functionalizing this MSNs with 3-Aminopropyl triethoxysilane (AP-MSNs) by post synthesis method, this nanoparticles characterized by SEM and FTIR analysis. Gallic acid(GA) was used as a natural anticancer drug which was loaded in AP-MSNs To optimize the GA loading in AP-MSNs, two effective parameters: GA concentration and embedding time were investigated. So different concentrations of GA in EtOH (1-50 mg/ml) were prepared and sampling was done in 24 and 48 hours. Results showed that the best GA loading into AP-MSNs was obtained at concentration of 40 mg/ml in 48 hours. The maximum loading and entrapment effeciency percent were obtained 46% and 20%, respectively, determined by spectrophotometry and high-performance liquid chromatography (HPLC) analysis.

کلیدواژه ها:

Nanoparticle ، Novel drug delivery ، Mesoporous silica ، Functionalization ، Gallic acid