Imaging Retinal Oxygen Levels in the Human Eye Using Scanning Laser Ophthalmoscope

سال انتشار: 1387
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 1,542

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شناسه ملی سند علمی:

ICMEDICALP08_036

تاریخ نمایه سازی: 19 شهریور 1387

چکیده مقاله:

This study investigated the feasibility of using a dual-wavelength (red and infrared) for assessing retinal oxygenation in the human eye by adapting a scanning laser ophthalmoscope (SLO) The ambition to monitor the localized supply and uptake of oxygen within the retina prompted the assessment of retinal perfusion. Our knowledge is not complete about retinal oxygenation in the human eye due to the invasive nature or/and technical shortcomings of the methods currently used. Optical techniques for measuring retina oxygenation are based on measuring the amount of light reflected at different wavelengths due to different light absorption spectra of the oxygenated and deoxygenated haemoglobin . The Aberdeen prototype SLO was adapted to use two wavelengths simultaneously to give the ability of imaging the perfusion in the human eye. This may allow the early detection of retinal disease such as diabetic retinopathy using spectral analysis of the retina status and replace fluorescent angiography in some cases . The technique was evaluated using measurements made on a model eye, fourteen volunteers’ normal eyes and seven eyes containing diabetic retinopathy . The scanning laser ophthalmoscope provides a number of unique features for retinal imaging that are not available with the conventional ophthalmoscope. So, the reproducibility of the measurements of reflected light from the eye using the Aberdeen SLO was investigated. A model eye was designed and varieties of different elements of the SLO using the model were studied . To image retinal oxygenation a new combination of two wavelengths (red and infrared) was chosen to produce a linear relationship between oxygen saturation and optical density ratio of blood vessels according to the Beer & Lambert law . The relative oxygen levels of retinal artery and vein were determined using this technique. The retinal perfusion imaging RPI is a new technique that was able to demonstrate the status of retinal oxygenation as relative oxygen saturation levels, which cannot be performed by the fluorescein angiogram.

نویسندگان

Seyed H Rasta

University of Aberdeen, UK, and Tabriz University of Medical Sciences, Iran