HN-02210215_The Effect of a High Antioxidant Enteral Nutrition Formula on Inflammatory Biomarkers, Metabolic Factors and Clinical Outcomes in Critically Ill Patients in The Intensive Care Unit: A Single-Blind Randomized Controlled Trial

Introduction: Critical illness is characterized by oxidative stress, which is recognized as an underlying cause for systemic inflammation and organ failure due to excessive production of free radicals, depletion of antioxidant defenses, or both. We hypothesized that a formula with high antioxidant agents could improve the inflammatory condition, metabolic status and clinical outcomes in critically ill patients. The aim of this study was to assess the efficacy of this formula compared to standard nutrition in critically ill patients in intensive care unit (ICU) patients.Methods: This single-center, prospective, randomized, single blind, controlled study was conducted on critically ill patient admitted to neurosurgical ICU. Patients were randomly assigned to receive either standard formula (n=10) or enriched formula (n=10). The primary outcomes were clinical outcomes, inflammatory biomarkers and metabolic tests including liver enzymes, blood sugar and lipid profile.Results: Compared with the standard formula, the enriched formula resulted in lesser elevation in hs-CRP level (17.560 ± 1.7437, p < 0.001) compared to the control group. Hs-CRP trend was significantly different between two groups (P = 0.007). There was a significant difference in trends of MAC (p<0.001), ALP (p<0.001) and LDL-c (P = 0.017) between groups. FBS, AST and TNF-α were not significantly different between groups.Conclusion: This study suggests that the antioxidant enriched formula maybe associated with improved inflammatory biomarkers, metabolic factors and clinical outcomes, including disease severity, in critically ill ICU patients. Further research with larger sample size and multicenter studies are needed to achieve better and reliable results.

کلیدواژه ها:

Inflammation ، Antioxidant ، Enteral Nutrition