HN-02190203_Effect of Probiotic and Conventional Yoghurt on Blood Glucose in Women with Gestational Diabetes Mellitus: A Randomized Placebo-Controlled Trial

Introduction: GDM is a complication of pregnancy that can be associated with neonatal complications and adverse pregnancy outcomes. Recently, probiotic use has been proposed for better control of glucose in GDM patients. The aim of this study was to compare the effect of probiotic yoghurt with ordinary yoghurt on GDM women.Methods: In this double-blind placebo-controlled clinical trial, 84 pregnant women with GDM were randomly assigned into two groups (n= 42) who received 300 grams/day of probiotic yoghurt or placebo for 8 weeks. Blood sugar, HbA1c, and pregnancy outcome were compared between groups after the intervention.Results: The mean ± SD age of participants was 31.6±5.7 years. The mean ± SD weight, height, and body mass index were 79.2±11.5 kg, 161.8±5.1 cm and 30.7±4.5 kg/m2; respectively. The mean ± SD systolic and diastolic blood pressures were 111.4±6.6 and 71.9±5.5 mmHg; respectively. No significant differences were observed in general characteristics between the two groups (p> 0.05). Both fasting and post prandial blood sugars as well as the level of HbA1C were decreased significantly in probiotic group (p<0.05), although these changes are not statistically significant in the placebo group. Neonates born of probiotic group mothers, have significantly lower weight and fewer macrosome neonates were born in this group (p<0.05). However, no difference was observed in other values of outcome.Conclusions: Our study revealed better control of blood glucose is achieved by consumption of probiotic yoghurt in women with GDM, compared to placebo. The incidence of macrosomia may be decreased by this regimen.

کلیدواژه ها:

Obesity ، Gestational diabetes mellitus ، Diabetes ، Probiotic ، Yoghurt