HN-02250219_Effects of berberine and barberry on anthropometric measures: A systematic review and meta-analysis of randomized controlled trials

Introduction: Despite controversies, no earlier study has systematically summarized findings from earlier studies on the effect of berberine and barberry on anthropometric measures. Therefore, current systematic review and meta-analysis was done on the effect of berberine and barberry on body mass index (BMI), body weight (BW), waist circumference (WC) and waist-hip ratio (WHR) in adults.Methods: Relevant studies published up to August 2019 were searched through PubMed/Medline, Scopus, ISI Web of Science, Embase and Google Scholar. All randomized clinical trials investigating the impact of berberine and barberry on any of the anthropometric measures including BMI, BW, WC or/and WHR were included.Results: Out of 252 citations, 12 trials that enrolled 849 subjects were included. Berberine and barberry resulted in not significant in BMI (Weighted Mean Differences (WMD): -0.16 kg/m2; 95% CI: -0.43 to 0.11, P=0.247), BW (WMD: −0.11 kg; 95% CI: −0.13 to 0.91, P=0.830), and berberine resulted in not significant in WC (WMD: −0.58 cm; 95% CI: −1.89 to 0.72, P=0.379) and significant reduction in WHR (WMD: -0.03; 95% CI: −0.04 to -0.01, P<0.0001).Conclusion: We found a significant reduction in WHR following berberine consumption in adults. Further clinical trials with high quality according to challenges mentioned seem to be helpful to use berberine and barberry as a supplement for certain health conditions, efficiently.

کلیدواژه ها:

berberine ، barberry ، anthropometric ، Randomized controlled trials ، Meta-analysis