Bioinformatics analysis of anti-amyloid agents as amyloid nanofibril inhibitors

Amyloid nanofibrils created by misfolding and aggregation of proteins are a major pathological feature ina variety of degenerative diseases. Aggregation of proteins, such as Aß in Alzheimer’s disease and a-Synuclein inParkinson’s disease, appears to lead to the formation of toxic aggregates. An attractive therapeutic strategy for amyloid’sdisease is to block the early steps of misfolding and aggregation of the soluble proteins. A vast range of diverse moleculeshave been studied as potential inhibitors of amyloid formation. The prediction of binding of small molecules to proteinswith molecular docking is of particular practical importance because it is used to screen virtual libraries of drug-likemolecules to obtain leads for further drug development. In the present study, we use bioinformatics' tool for showinteraction between inhibitory compounds with a-synuclein protein that inhibited the assembly of α-synuclein intofilaments in vitro.

کلیدواژه ها:

Amyloid nanofibril ، Amyloid inhibition ، Molecular docking ، a-synuclein