Adsorption of Doxorubicin Anti Cancer Drug on the Magnetic Silica Core Shell Nanocomposite

In this study, adsorption of doxorubicin anticancer drug on the magnetic/silica core shell nanocomposite isinvestigated. The main core of the particles is composed of superparamagnetic iron oxides (Fe3O4) microsphere whichwas synthesized by applying a very simple solvothermal method. The shell of the nanocomposites contains silica that arefunctionalized with amine and folic acid groups to produce a strong interaction between drug and nanocomposite. Thesize of the core shell nanocomposite was checked with dynamic light scattering (DLS) analyses that shows a uniqueparticle size around 41 nm. This particle size is appropriate for drug delivery systems. The presence of the functionalgroups was checked using FTIR analysis. The adsorption efficiency of the drug was calculated using UV visible analysis.Adsorption results show that doxorubicin drug is adsorbed on the nanocomposite surface with 81% efficiency.

کلیدواژه ها:

Nanocomposite ، Super paramagnetic ، Core Shell ، Drug delivery ، Anti cancer Drug