Evaluation of Lipid-based Drug Delivery System (Nanosolve) on Oral Bioavailability of Dibudipine

The objective of present study was to evaluate pharmacokinetic parameters of dibudipine Nanosolve afteroral administration in rats. The solubility test was carried out to select suitable oily solvent for dibudipine. Nanosolveformulation was prepared with a medium chain triglyceride (MCT) oil (20%), soybean phospholipids (5%) and a 70%fructose solution (75%). The effect of polyol content on the mean globule size of Nanosolve formulation was studied.The optimized formulation was evaluated for robustness toward dilution, transparency, droplet size, zeta potential andtransmission electron microscopic analysis. The Nanosolve of dibudipine with an average droplet size of 142.3±4.3 nmand surface charge -18.36±0.37 mv was administered orally to rats. The average relative bioavalabilities of dibudipinein the plasma with Nanosolve were 170.4% and 211.2% as compared to the oily solution and aqueous suspensionrespectively. So this formulation could be offered as a useful technique to improve the oral delivery of the poorly watersoluble drugs such as dibudipine.

کلیدواژه ها:

Dibudipine ، Nanosolve ، Bioavailability ، Solubility ، Lipid-based formulation