Therapeutic Effects of Aqueous Extracts of Cerasus avium Tail on Ethylene Glycol- Induced Kidney Calculi in Rats

سال انتشار: 1395
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 559

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شناسه ملی سند علمی:

ICRSIE02_237

تاریخ نمایه سازی: 11 مرداد 1396

چکیده مقاله:

Aim: to investigate the therapeutic effects of the aqueous extract of cherry tails on kidney calculi. Methods: In this experimental study, forty-eight (48) male Wistar rats were randomly allocated into six (6) groups and were studied during a 30 day period. Group A served as normal control and Group B received 1% ethylene glycol in drinking water(EG group). C,D,E, and F Groups, received 1% ethylene glycol from day 1 and were used as prevention and treatment subjects. Rats in prevention groups of low dose (C) and high dose (D) extract, were gavaged with 200 and 400 mg/kg extract respectively from first day of the experiment and treatment groups of low dose (E) and high dose (F) extract, gavaged with 200 and 400 mg/kg extract respectively from the 15th day of the experiment. Results: On the 30th days of the experiment, serum level of magnesium and potassium decreased significantly in EG group compared with A,C,D,E and F groups (P<0.05), while serum level of calcium and sodium increased significantly in EG group compared with A,C,D,E and F groups (P<0.05). In the prevention and treatment groups, the number of deposits decreased significantly compared with EG group on the 30th day (P<0.01). The weight of the kidneys increased significantly in EG group compared with A,C,D, and F groups. Conclusion: Cherry tail has a therapeutic effect on calcium oxalate stones in rats with nephrolithiasis and reduces the number of calcium oxalate deposits.

نویسندگان

Ehsaneh Azaryan

Biochemistry Department, payamenoor university of Mashhad, Mashhad,Iran

Mohammad malekaneh

Biochemistry Department, Birjand Uniniversity of Medical sciences, Birjand, Iran

Fatemeh Haghighi

Pathology Department, Birjand Uniniversity of Medical sciences, Birjand, Iran