EVALUATING THE ACCURACY AND SENSITIVITY OF ANTHROPOMETRIC AND LABORATORY VARIABLES IN DIAGNOSING THE LIVER STEATOSIS AND FIBROSIS IN ADOLESCENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE

Background and Aim: Background/purpose: Non-alcoholic fatty liver disease is a common chronic disease in this modern world and varied from a silent disease to advanced cirrhosis and hepatocellular carcinoma. Making the diagnosis in the silent stage is valuable in preventing disease progression to progressive phase of the disease. The purpose of this study is evaluation and comparison of sensitivity and specificity of anthropometric parameters and laboratory data in diagnosing fatty liver disease.Methods: Methods: A total sample of 70 overweight and obese children and adolescents were recruited from those admitted to a nutrition clinic in Mashhad, northeastern Iran. The diagnosis of NAFLD was determined by Fibro scan and ultrasound. Anthropometric parameters and liver function test were measured with standard methods. The sensitivity as well as specificity of anthropometric and laboratory values were detected by receiver operating characteristic analysis. Conclusion: Results: In 70 pediatric and adolescent subjects 37 (52.9%) subjects were male and 33 (47.1%) subjects were female with an average age of 12.75 ± 2.81 year-old. In detecting liver steatosis, the AUC of BMI (0.764) and WC (0.754) and about liver fibrosis the AUC of WC (0.704) was higher than BMI (0.652). Between laboratory tests AST/ALT had the most AUC (0.604) in predicting liver steatosis. With regarding to liver fibrosis ALT had the most AUC (0.692). In predicting liver fibrosis followed by GGT (0.689), AST/ALT (0.684), AST (0.634) and AST/PLT (0.625). Ultrasound had AUC of 0.69 in predicting liver steatosis and AUC of 0.646 in predicting liver fibrosis. The sensitivity and specificity of ultrasound was only 47.06% and 59.09% respectively for grade one steatosis. Conclusion: Anthropometric parameters such as waist circumference and BMI have the best performance in diagnosis of liver steatosis and fibrosis in comparison with ultrasonography and laboratory test in adolescents.

کلیدواژه ها:

Nonalcoholic fatty liver disease (NAFLD) ، Fibro scan ، Anthropometric parameter ، Laboratory variable ، Adolescence