DIETARY TOTAL ANTIOXIDANT CAPACITY AND GESTATIONAL DIABETES MELLITUS: A CASE-CONTROL STUDY

Background and Aim: Studies have indicated severe oxidative stress status among pregnant women with gestational diabetes mellitus (GDM). In diabetic condition, glucose and lipid peroxidation, and alteration in antioxidant defense lead to increased amount of free radicals. This study aimed to investigate the association between dietary total antioxidant capacity (DTAC) and GDM.Methods: This hospital-based case-control study was conducted among 463 pregnant women (healthy= 263, GDM= 200). Anthropometric indices, blood pressure and biochemical tests were measured. Dietary intake was assessed by the average of three 24-h dietary records. DTAC was calculated by three indices: Ferric Reducing Ability of Plasma (FRAP), Total Radical-trapping Antioxidant Parameter (TRAP), and Trolox Equivalent Antioxidant Capacity (TEAC). Multivariable logistic regression was performed to examine the relationship between DTAC and GDM risk in crude and adjusted models.Results: The mean age and BMI were 28.33 ± 6.23 years and 29.67 ± 4.73 kg/m2, respectively. Total energy, protein, and selenium intakes were significantly higher in cases than controls (P< 0.05). Moreover, intakes of carbohydrate, vitamins C, B6 and A, manganese, fruits, fruit juices, vegetables, legumes, and FRAP were significantly lower in cases than controls (P< 0.05). The risk of gestational diabetes mellitus was 85% lower among those in the highest tertile of FRAP. Conclusion: Pregnant women who were in the highest tertile of FRAP were at lower risk of GDM. However, larger prospective studies needed to confirm our findings.

کلیدواژه ها:

Dietary total antioxidant capacity ، gestational diabetes ، antioxidant ، Ferric Reducing Ability of Plasma ، pregnancy