EFFECT OF CARNOSINE SUPPLEMENTATION ON ADVANCED GLYCATION AND LIPOXIDATION END PRODUCTS IN AUTISTIC CHILDREN: A RANDOMIZED CONTROLLED CLINICAL TRIAL

Background and Aim: Several pieces of evidence indicated the increased levels of oxidative stress in autistic patients. Advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs) are compounds that can be produced under oxidative stress conditions. Carnosine is a naturally occurring dipeptide with anti-glycation effects. The aim of this article was to evaluate the effects of carnosine on the AGEs and ALEs in autistic patients.Methods: This randomized double-blind, placebo-controlled clinical trial was conducted on 36 children with autism, 18 in the carnosine group and 18 in the placebo group. The groups received a daily supplement of 500 mg carnosine or placebo for two months, respectively. ELISA method was used for evaluation of plasma levels of glycation and lipoxidation markers. Results: In all, most of the autistic children were in normal nutritional status (63.9%). After carnosine supplementation, plasma levels of AGEs and of ALEs did not change significantly in autistic children.Conclusion: The findings of this trial indicate that carnosine supplementation could not alter the levels of AGEs and of ALEs in autistic children.

کلیدواژه ها:

Autism ، Oxidative stress ، Carnosine ، Advanced glycation end products ، Advanced lipoxidation end products