RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CLINICAL TRIAL STUDYING THE EFFECTS OF TURMERIC IN COMBINATION WITH MEFENAMIC ACID IN PATIENTS WITH PRIMARY DYSMENORRHOEA

Background and Aim: Primary dysmenorrhea (PDM), a pain with no proven organic disease, is one of the common complaints in women. Due to its prevalence, our study aimed to assess the effects of turmeric and mefenamic acid and a combination compared with placebo on PDM.Methods: This two-month clinical trial was conducted on dormitory students with PMD. The students, who were qualified, completed the visual analog scale (VAS) before randomization. Classification was indicated following the severity of the pain (mild 0–3; moderate 3.1–6; severe 6.1–10). One hundred twenty-eight patients, randomly assigned to one of following groups. Turmeric group (n=32), mefenamic acid group (n=32), turmeric and mefenamic acid group (n=32), and placebo group (n=32). Turmeric and mefenamic acid were administrated in 500 mg and 250 mg, respectively. Pain severity was assessed in the baseline and the end line by VAS. Statistical analysis was performed using SPSS software.Results: Turmeric and mefenamic acid, individually reduced menstrual pain, however, the combination of turmeric and mefenamic acid, dramatically, alleviated pain in comparison to other groups. Conclusion: Our results illustrated that combination of turmeric and mefenamic acid would be better in pain alleviation in PMD and use of them may be useful in decreasing of dysmenorrhea pain.

کلیدواژه ها:

Primary dysmenorrhea ، Turmeric ، Mefenamic acid