CORRELATION BETWEEN NUTRIENTS INTAKE AND INFLAMMATORY PARAMETERS IN WOMEN WITH KNEE OSTEOARTHRITIS

Background and Aim: Osteoarthritis (OA) is a progressive rheumatic disease and inflammation has been implicated as an important factor in the development and progression of OA and in symptoms such as pain. This study aimed to assess the correlation between nutrients intake and inflammatory parameters in women with knee OA. Methods: A total of 70 knee OA women (mean age: 52.05±6.13 years) were recruited from the rheumatology clinic of Tabriz University of Medical Sciences. Dietary intake was evaluated using a 24-hour recall method for 3 days (including 2 working days and 1 weekend). Serum levels of interleukine-1β (IL-1β), matrix metalloproteinases (MMPs)-1 and -13 were assessed. Correlations between variables were analyzed by Pearson and Spearman correlation analysis, as appropriate.Results: The mean±SD and median (IQR) IL-1β, MMP-1, and MMP-13 were 9.83±1.57, 409 (219.0, 1049.0), and 74.0 (36.0, 173.0), respectively. Total energy and carbohydrate intake correlated significantly with serum IL-1β (r=0.256, P=0.038 and r=0.246, P=0.047, respectively) and MMP-1 levels (r=0.259, P=0.034 and r=0.257, P=0.036, respectively). Furthermore, PUFA intake was only correlated significantly with IL-1β (r=0.273, P=0.026). Dietary manganese intake was significantly correlated with serum MMP-1 (r=0.261, P=0.033) and MMP-13 (r=0.304, P=0.012) levels. Moreover, there was significant correlation between dietary zinc and serum MMP-1 level (r=0.270, P=0.027). No significant correlation was found between dietary protein, calcium, phosphorous, magnesium, selenium and vitamin intake with inflammatory parameters. Conclusion: This study suggested a potential role of nutrients in cartilage loss and disease progression in patients with knee OA; however these findings warrant further confirmation

کلیدواژه ها:

L-carnitine ، Nutrients ، Inflammatory parameters ، Knee osteoarthritis