EFFECTS OF THE PALEOLITHIC DIET ON GLUCOSE CONTROL IN ADULTS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CONTROLLED CLINICAL TRIALS

Background and Aim: Although the results were conflicting, the Paleolithic diet (PD) is proposed to be effective in improvement of metabolic status. We aimed to perform a systematic review and meta-analysis of randomized controlled clinical trials (RCTs) evaluating the effect of the PD on glycemic markers.Methods: Online databases such as PubMed, Scopus, ISI Web of Science, Google Scholar were searched up to December 2017 without any restrictions. The weighted mean difference (WMD) was calculated using random effects model. Results: Eventually, 8 studies which most of them had good quality were included in the present systematic review and meta-analysis. The pooled analysis showed that although adherence to the PD led to reduction in fasting blood glucose (FBG) concentrations, it was no statistically significant (WMD = -0.31, 95% CI: -0.70, 0.07, P = 0.11). Moreover, compared with the control diets, the PD consumption did not significantly affect other glycemic markers such as 2-h post-prandial blood glucose (2h PBG), insulin, homeostasis model assessment for insulin resistance (HOMA-IR), and Hemoglobin A1c (HbA1c).Conclusion: Adherence to the PD had no significant effects on glycemic markers, although a non-significant reduction in FBG levels was observed.

کلیدواژه ها:

Paleolithic Diet ، Glycemic Markers ، Systematic Review ، Meta-analysis