DIETARY FAT INTAKE AND RISK OF OVARIAN CANCER: A SYSTEMATIC REVIEW AND DOSE-RESPONSE META-ANALYSIS OF OBSERVATIONAL STUDIES

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 433

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شناسه ملی سند علمی:

INC15_523

تاریخ نمایه سازی: 30 دی 1397

چکیده مقاله:

Background and Aim: Observational studies have reported controversial evidence of the association between dietary fat intake and ovarian cancer. This dose-response meta-analysis aimed to clarify quantitatively the association between dietary fat intake and ovarian cancer.Methods: We searched the PubMed, Scopus and ISI Web of Science databases up to November 2017. Risk ratios (RRs) and 95% confidence intervals (95% CI) were calculated using a fixed effects model for highest versus lowest intake categories. The linear and non-linear relationships between fat intake and risk of ovarian cancer were investigated. Heterogeneity, sensitivity analysis and publication bias were also assessed.Results: Overall, 21 studies (9 cohort and 12 case-control studies) involved approximately 900,000 subjects were included. A significant nonlinear association was found between total fat intake with the risk of ovarian cancer, with a relatively steep slope at total fat intake higher than 30 g/day (p non-linearity< 0.01). Moreover, the risk of ovarian cancer was increased in non-linear form for both saturated and monounsaturated fat from 25g/day (p non-linearity<0.05). According to the findings from linear meta-analysis, we observed a 2, 2, 1 and 1% greater risk of ovarian cancer per 10, 0.5, 2.5g/day and 50mg/day increase in total, trans and monounsaturated fat intake as well as cholesterol, respectively. However, this association for monounsaturated fat (p=) and cholesterol (p=) was marginally significant. Conclusion: The findings of this meta-analysis suggest that dietary total, trans, saturated and partially monounsaturated fat as well as cholesterol intake is positively associated with increased risk of ovarian cancer.

نویسندگان

Alireza Sadeghi

Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran