EFFECT OF VITAMIN D SUPPLEMENTATION ON METABOLIC AND ANTHROPOMETRIC MARKERS IN SUBJECTS WITH METABOLIC SYNDROME

Background and Aim: The evidence in support of the effect of vitamin D deficiency on cardiovascular diseases is inconsistent. The objective of this randomized, controlled, double-blind study was to assess the effect of vitamin D supplementation on metabolic and anthropometric markers in subjects with metabolic syndrome. Methods: Eighty subjects were randomized to receive 50,000 IU vitamin D or matching placebo weekly for 16 weeks. Fasting blood sugar (FBS), homeostasis model assessment of insulin resistance (HOMA-IR), insulin sensitivity (Quicki), serum lipid profiles (low density lipoprotein cholesterol [LDL-C], high density lipoprotein cholesterol [HDL-C], triglyceride (TG), and total cholesterol), anthropometric factors, and blood pressure were assessed before and after intervention. Dietary intake and sun exposure were also determined. The trial was registered at http://www.irct.ir (No. 201409033140N14).Participants were 40.49±5.04 y and 49% male. All of the intervention group and 97% of placebo group were vitamin D deficient or insufficient (25-hydroxy vitamin D<75 nmol/L). After intervention, serum 25(OH)D concentration was increased by 61.93 nmol/L in intervention group while it was decreased in placebo group (p<0.001). There was a significant change in TG concentration after four months (p<0.001). Other metabolic or anthropometric factors did not change significantly (p> 0.05). Conclusion: Supplementation with vitamin D for four months improved vitamin D status and decreased TG levels in subjects with metabolic syndrome. However, it did not have any beneficial effects on other metabolic or anthropometric markers. this study did not support the beneficial effect of vitamin D on cardiometabolic risk factors.

کلیدواژه ها:

vitamin D ، metabolic ، inthropometric markers ، metabolic syndrome ،